Carbon Tetrachloride → 2-(Chloromethyl)-5-(1,2-oxazol-3-yl)pyridine

HRID 271469

Reaktionsgleichung

Reaktionsgleichung von HRID 271469
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1.C(Cl)(Cl)(Cl)[Cl:14].ClN1C(=O)CCC1=O>CCOC(C)=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Cl:14][CH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][O:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 5943Carbon TetrachlorideHCID 31398Chlorosuccinimide2×HCID 598348122-Methyl-5-(1,2-oxazol-3-yl)pyridine

Produkt 1

HCID 598348302-(Chloromethyl)-5-(1,2-oxazol-3-yl)pyridineAusbeute 34 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 7187Benzoyl PeroxideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a stirring mixture of 3-(6-methylpyridin-3-yl)isoxazole (76 mg, 0.474 mmol) and 6 mL carbon tetrachloride, was added N-chlorosuccinimide (69.7 mg, 0.52 mmol), followed by 3 mg benzoyl peroxide. The reaction mixture was refluxed. Additional N-chlorosuccinimide (40 mg, 0.30 mmol) was added in two portions after stirring 2 h and 4 h. After refluxing for a total of 13 h the reaction mixture was diluted with EtOAc, then washed sequentially with 1 N aq. NaOH solution, water and saturated aqueous NaCl. The organic phase was dried (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by automated silica gel chromatography (eluted with ethyl acetate-hexanes) to isolate 31 mg (34%) of the title compound as a white solid. HPLC/MS: retention time=1.77 min, [M+H]+=195.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed
  2. temperatureAfter refluxing for a total of 13 h the reaction mixture
  3. washwashed sequentially with 1 N aq. NaOH solution, water and saturated aqueous NaCl
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe crude product was purified by automated silica gel chromatography (eluted with ethyl acetate-hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-45b2a6bef758469b9fa314c84e355dcd
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452892B2

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