Methanol → Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate

HRID 271583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 271583
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15](=[O:18])([O-])[O-].[NH4+:19].[NH4+:20].[C-]#N.[Na+].[CH3:24][OH:25]>O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2([NH:20][C:24](=[O:25])[NH:19][C:15]2=[O:18])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 8929Sodium CyanideHCID 517111Ammonium CarbonateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Produkt 1

HCID 3629994Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

To a solution of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (30.0 g, 151 mmol) in MeOH (100 ml), H2O (40 ml), ammonium carbonate (331 mmol) and sodium cyanide (226 mmol) in H2O (60 ml) are added successively at ambient temperature. The reaction mixture is stirred at ambient temperature for 18 h to give precipitates, which are filtered off and washed with H2O and ether on the filter.

Aufarbeitung

  1. customto give
  2. customprecipitates
  3. filtrationwhich are filtered off
  4. washwashed with H2O and ether on the filter

Quellen und Nachweise

ORD-Eintrag
ord-1ca84f2ff9f141c9b27bb55cbb4e946b
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452886B2

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