Hydrochloric Acid → 5-(4-Chloro-phenyl)-2-{4-[2-(4-isopropyl-piperidin-1-yl)-ethoxy]-3-methyl-phenylethynyl}-pyridine

HRID 271722

Reaktionsgleichung

Reaktionsgleichung von HRID 271722
[CH:1]([CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl.CS(O[CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][CH:34]=3)=[CH:29][N:28]=2)=[CH:21][C:20]=1[CH3:40])(=O)=O.C(N(C(C)C)C(C)C)C>CN(C=O)C>[Cl:39][C:36]1[CH:37]=[CH:38][C:33]([C:30]2[CH:31]=[CH:32][C:27]([C:26]#[C:25][C:22]3[CH:23]=[CH:24][C:19]([O:18][CH2:17][CH2:16][N:7]4[CH2:8][CH2:9][CH:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]4)=[C:20]([CH3:40])[CH:21]=3)=[N:28][CH:29]=2)=[CH:34][CH:35]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 140569Piperidine, 4-(1-methylethyl)-HCID 865946832-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]-2-methylphenoxy}ethyl methanesulfonate

Produkt 1

HCID 598357425-(4-Chloro-phenyl)-2-{4-[2-(4-isopropyl-piperidin-1-yl)-ethoxy]-3-methyl-phenylethynyl}-pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

164 mg (1.0 mmol) 4-isopropyl-piperidine (used as the hydrochloride) are added to a solution of 88 mg (0.2 mmol) 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-2-methyl-phenoxy}-ethyl methanesulphonate and 0.34 mL (2 mmol) ethyldiisopropylamine in 1.8 mL DMF and the reaction mixture is stirred for 24 h at RT. It is filtered using an injection filter and the reaction mixture is purified by HPLC.

Aufarbeitung

  1. filtrationIt is filtered
  2. filtrationfilter
  3. customthe reaction mixture is purified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-00fad2629e584cde995d3f27007d42fa
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452911B2

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