5-Bromo-8-nitroisoquinoline → 5-Bromoisoquinolin-8-amine

HRID 272775

Reaktionsgleichung

Reaktionsgleichung von HRID 272775
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.[H][H]>[Pt].C(O)(=O)C>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

Komponenten

5

Edukt 2

HCID 8169835-Bromo-8-nitroisoquinolineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 162183025-Bromoisoquinolin-8-amineAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A mixture of Example 801A (500 mg, 2 mmol), 5% Pt/C and acetic acid (50 mL) was equipped with a balloon of hydrogen gas and stirred at room temperature. When the reaction was complete, the solution was filtered through Celite. The mixture was treated with 50% sodium hydroxide solution until pH reached 10. Filtration provided 267 mg (60%) of the desired product as a yellow solid. MS (ESI) m/e 223 (M+H)+.

Aufarbeitung

  1. filtrationthe solution was filtered through Celite
  2. additionThe mixture was treated with 50% sodium hydroxide solution until pH
  3. filtrationFiltration

Quellen und Nachweise

ORD-Eintrag
ord-edf2fdf58e13430cb897e04894003c20
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456169B2

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