Hydrochloric Acid → HCID 23342859, Verbindung

HRID 27407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 27407
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[OH-:13].[Na+].Cl.C(Cl)(Cl)Cl>O.C(O)C>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([OH:13])=[O:1]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 23342878HCID 23342878, Verbindung

Produkt 1

HCID 23342859HCID 23342859, VerbindungAusbeute 30,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

67.6 g (0.4 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone and 32 g (0.8 mol) of sodium hydroxide in 210 ml of water are heated for 2 hours under reflux, cooled and then acidified with hydrochloric acid to a pH value of 1. The reaction mixture is evaporated to dryness under reduced pressure and the residue taken up three times in benzene and evaporated in vacuo. The residue obtained is finally treated with a mixture of chloroform and ethanol (4:1 v/v) and the insoluble material filtered off. The filtrate is evaporated and the residue is recrystallized from ethanol. 22.7 g (yield: 30% of theory) of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetic acid are obtained. M.P.: 123°-124° C.

Aufarbeitung

  1. temperatureunder reflux
  2. temperaturecooled
  3. customThe reaction mixture is evaporated to dryness under reduced pressure
  4. customevaporated in vacuo
  5. customThe residue obtained
  6. filtrationthe insoluble material filtered off
  7. customThe filtrate is evaporated
  8. customthe residue is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-99b428fde9a147f19afbe43967e2b0bf
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221789

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