Hydrochloric Acid → HCID 20092143, Verbindung

HRID 274186Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 274186
[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Br[CH:25]([O:27][CH2:28][CH3:29])[CH3:26].[OH-].[Na+].Cl>O.C(O)C>[CH2:1]([O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH2:26][CH2:25][O:27][CH2:28][CH3:29])=[C:18]([F:23])[N:17]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 145479151-Bromo-1-ethoxyethaneHCID 190469612-(4-Octyloxyphenyl)-5-hydroxy-6-fluoropyridine

Produkt 1

HCID 20092143HCID 20092143, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 0.1 mol of 2C, 0.1 mol of 1-bromoethoxyethane, 0.1 mol of sodium hydroxide, 20 ml of ethanol and 50 ml of water is heated at the boil for 2 hours. The mixture is cooled, dilute hydrochloric acid is added, and the aqueous phase is extracted with dichloromethane. The solvent is removed under reduced pressure, and the residue is purified by column chromatography, giving the product 2-(4-octyloxyphenyl)-5-(2-ethoxyethoxy)-6-fluoropyridine.

Aufarbeitung

  1. temperatureis heated at the boil for 2 hours
  2. temperatureThe mixture is cooled
  3. extractionthe aqueous phase is extracted with dichloromethane
  4. customThe solvent is removed under reduced pressure
  5. customthe residue is purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4e0bc83878c14500884c11b6594ab2ff
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389291

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