4'-Chloropropiophenone → 2-Bromo-1-(4-chlorophenyl)propan-1-one

HRID 274341

Reaktionsgleichung

Reaktionsgleichung von HRID 274341
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.[Br:12]Br>C(Cl)(Cl)Cl.[Cl-].[Al+3].[Cl-].[Cl-]>[Br:12][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)=[O:11]

Komponenten

5

Edukt 2

HCID 226974'-ChloropropiophenoneHCID 24408Bromine

Produkt 1

HCID 37882192-Bromo-1-(4-chlorophenyl)propan-1-oneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6451240Aluminum(III) ChlorideKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

4'-chloropropiophenone (39.6 g) and anhydrous aluminum chlorid (0.1 g) were dissolved in 100 ml of chloroform. To the resulting solution was protionwise added bromine (37.6 g) at a temperature of 30° to 35° C. The reaction mixture was stirred at room temperature for 30 minutes. Then nitrogen was blown into the reaction mixture to remove the formed hydrogen bromide therefrom. Thereafter, the solvent was distilled off under reduced pressure to give 2-bromo-4'-chloropropiophenone (58.1 g). mp 77.5°-79.5° C.

Aufarbeitung

  1. customat a temperature of 30° to 35° C
  2. customto remove the formed hydrogen bromide
  3. distillationThereafter, the solvent was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e7e3e66bcd3044e68b419873ba254cb4
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389648

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