Ammonia → 4-cyano-1H-pyrrole-2-carboxamide
Reaktionsgleichung
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([C:10]#[N:11])[CH:9]=1)=[O:4].[NH3:14]>CO.O>[C:10]([C:8]1[CH:9]=[C:5]([C:3]([NH2:14])=[O:4])[NH:6][CH:7]=1)#[N:11]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 2-trichloroacetylpyrrole-4-carbonitrile (20 g, 84.2 mmol) in methanol is treated with ammonia (51 mL), stirred at room temperature for 30 minutes and diluted with water. The aqueous mixture is filtered to obtain the title product as a white solid (7.0 g, mp 253°-256° C.).
Aufarbeitung
- filtrationThe aqueous mixture is filtered
Quellen und Nachweise
- ORD-Eintrag
- ord-d13606e42b364f86abc512497f317646
- Quelldatensatz
- uspto-grants-1995_02
- Patentnummer
- US05389669
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