Potassium Hydroxide → 4-(2,3-Dichlorophenyl)-1H-pyrrole-3-carboxylic acid

HRID 274737Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 274737
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([C:14]([O:16]CC)=[O:15])=[CH:11][NH:12][CH:13]=1.[OH-].[K+]>O>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[C:10]([C:14]([OH:16])=[O:15])=[CH:11][NH:12][CH:13]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 15239092ethyl 4-(2,3-dichlorophenyl)-1H-pyrrole-3-carboxylate

Produkt 1

HCID 152390934-(2,3-Dichlorophenyl)-1H-pyrrole-3-carboxylic acidAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of ethyl 4-(2,3-dichlorophenyl)pyrrole-3-carboxylate (5.95 g, 21 mmol) and potassium hydroxide (6.5 g, 85%, 99 mmol) is heated at reflux for 6 hours, cooled, diluted with water and washed with diethyl ether. The aqueous phase is acidified with hydrochloric acid and filtered to obtain a solid. The solid is washed with diethyl ether and petroleum ether and dried to give the title product as a white solid (5.24 g) which is identified by 1H and 13C NMR spectral analyses.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux for 6 hours
  3. temperaturecooled
  4. washwashed with diethyl ether
  5. filtrationfiltered
  6. customto obtain a solid
  7. washThe solid is washed with diethyl ether and petroleum ether
  8. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7de814f62de34bd1b8e5fd555380480c
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389669

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