Cysteamine Hydrochloride → 2-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochloride

HRID 27475

Reaktionsgleichung

Reaktionsgleichung von HRID 27475
[ClH:1].O[CH2:3][C:4]1[N:5]=[CH:6][NH:7][C:8]=1[CH3:9].Cl.[NH2:11][CH2:12][CH2:13][SH:14]>Cl.C(O)(C)C>[ClH:1].[ClH:1].[CH3:9][C:8]1[N:7]=[CH:6][NH:5][C:4]=1[CH2:3][S:14][CH2:13][CH2:12][NH2:11]

Komponenten

5

Edukt 2

HCID 9082Cysteamine HydrochlorideHCID 30847074-Methylimidazol-5-ylmethanolhydrochloride

Produkt 1

HCID 30159992-(((5-Methyl-1H-imidazol-4-yl)methyl)thio)ethylamine dihydrochlorideAusbeute 164,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

Aufarbeitung

  1. temperatureunder reflux for 17 hours
  2. concentrationConcentration
  3. customfollowed by re-evaporation with water
  4. customafforded a residue which
  5. concentrationconcentrated to low bulk
  6. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-9d4a886ceb724adbb862d5e6bfc3186b
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221802

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