1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 274762

Reaktionsgleichung

Reaktionsgleichung von HRID 274762
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

Komponenten

4

Edukt 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

Produkt 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a suspension of 1-hydroxy-2-naphthoic acid (2.5 g; 13.3 mm) in chloroform (50 ml) was added bromine (0.68 ml) in chloroform (5 ml) dropwise and the reaction stirred at room temperature for one hour. The solvent was removed in vacuo, the solid washed repeatedly with water and collected by filtration and dried to give 4-bromo-1-hydroxy-naphthalene-2-carboxylic acid as a white solid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. washthe solid washed repeatedly with water
  3. filtrationcollected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-657abbb53a14432ebc0bf161407cc8a6
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389684

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