Water → HCID 20088899, Verbindung

HRID 274877

Reaktionsgleichung

Reaktionsgleichung von HRID 274877
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:13]([C:21]([O-:23])=[O:22])=[N:14][C:15]([N:18]([CH3:20])[CH3:19])=[CH:16][CH:17]=2)[N:4]=1.[K+].[CH2:25]([O:27][C:28]([O:30][CH:31](Cl)[CH3:32])=[O:29])[CH3:26].O>CN(C)C=O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][C:12]2[C:13]([C:21]([O:23][CH:25]([O:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH3:26])=[O:22])=[N:14][C:15]([N:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=2)[N:6]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 162095Carbonic acid, 1-chloroethyl ethyl esterHCID 23710069HCID 23710069, Verbindung

Produkt 1

HCID 20088899HCID 20088899, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2.0 g (5.6 mmol) of potassium 3-(4,6-dimethoxypyrimidin-2-yl)oxy-6-dimethylaminopicolinate and 0.8 g (5.7 mmol) of 1-(ethoxycarbonyloxy) ethylchloride were suspended in 5 ml of dimethylformamide, and were stirred at room temperature for 6 hours. The reaction mixture was poured into water, and was extracted with ethyl acetate twice. The organic layer was then washed with water and dried, and the solvent was distilled off to obtain a viscous product which was then column-purified to obtain an aimed compound.

Aufarbeitung

  1. extractionwas extracted with ethyl acetate twice
  2. washThe organic layer was then washed with water
  3. customdried
  4. distillationthe solvent was distilled off
  5. customto obtain a viscous product which
  6. customwas then column-purified

Quellen und Nachweise

ORD-Eintrag
ord-4e6006c90f2948af92b946712e3570a3
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05391537

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