Sulfuryl chloride → Ethyl 2-chloro-3-oxopentanoate

HRID 27489

Reaktionsgleichung

Reaktionsgleichung von HRID 27489
S(Cl)([Cl:4])(=O)=O.[O:6]=[C:7]([CH2:14][CH3:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)(Cl)Cl>[Cl:4][CH:8]([C:7](=[O:6])[CH2:14][CH3:15])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Komponenten

4

Edukt 2

HCID 24648Sulfuryl chlorideHCID 78656Ethyl 3-oxovalerate

Produkt 1

HCID 12923424Ethyl 2-chloro-3-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

Aufarbeitung

  1. additionaddition the mixture
  2. temperatureheated
  3. temperatureunder reflux for 0.5 hour
  4. temperaturecooled
  5. washAfter washing with water, sodium bicarbonate and water
  6. dry with materialthe solution was dried (sodium sulphate)
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4bf2e9ed074343889166e28dfcebce1b
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221802

Verknüpfte Notizen

Wird geladen…