4-(Trifluoromethyl)phenylhydrazine → 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone

HRID 275258

Reaktionsgleichung

Reaktionsgleichung von HRID 275258
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([OH:12])=O)=[O:7].[F:22][C:23]([F:33])([F:32])[C:24]1[CH:29]=[CH:28][C:27]([NH:30][NH2:31])=[CH:26][CH:25]=1>CO.C1(C)C=CC(S(O)(=O)=O)=CC=1>[F:22][C:23]([F:32])([F:33])[C:24]1[CH:25]=[CH:26][C:27]([NH:30][N:31]=[C:10]([OH:12])[C:9]2[CH:13]=[CH:14][CH:15]=[N:16][C:8]=2[C:6](=[O:7])[C:5]2[CH:17]=[CH:18][CH:19]=[C:3]([C:2]([F:1])([F:21])[F:20])[CH:4]=2)=[CH:28][CH:29]=1

Komponenten

5

Edukt 2

HCID 1362004-(Trifluoromethyl)phenylhydrazineHCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

Produkt 1

HCID 1785195602-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazoneAusbeute 80,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6101p-Toluenesulfonic acidKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(3-Trifluoromethylbenzoyl)nicotinic acid (0.5 g), 4-trifluoromethylphenylhydrazine (0.3 g) and para-toluene sulphonic acid (0.001 g) were stirred in methanol at room temperature for 22 hours. Solvent was evaporated. The residue was triturated in cold toluene then dried to yield the title compound as a beige solid (0.62 g), m.p. 127°-129° C.

Aufarbeitung

  1. customSolvent was evaporated
  2. customThe residue was triturated in cold toluene
  3. customthen dried

Quellen und Nachweise

ORD-Eintrag
ord-0f21748979904a6cb9e4027cefd1fe85
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05393730

Verknüpfte Notizen

Wird geladen…