2-Bromopropane → 2,3-Dimethyl-1-(2-propyl)oxybenzene

HRID 275725

Reaktionsgleichung

Reaktionsgleichung von HRID 275725
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH:17]([CH3:19])[CH3:18]>CC(C)=O>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH:17]([CH3:19])[CH3:18]

Komponenten

5

Edukt 3

HCID 63582-BromopropaneHCID 106872,3-DimethylphenolHCID 11430Potassium Carbonate

Produkt 1

HCID 203083562,3-Dimethyl-1-(2-propyl)oxybenzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a stirred solution/suspension of 2,3-dimethylphenol (10 g) and potassium carbonate (6.8 g) in acetone (150 ml) at reflux was added 2-bromopropane (46 ml) drop-wise over 30 min. The solution was heated at reflux for 4 days. After cooling, the solvent was evaporated and the residue was dissolved in ether and water. The ether phase was separated and was worked up according to the general procedure. Column chromatography on silica gel (eluent:ethyl acetate/heptane 1:19) afforded pure 2,3-dimethyl-1-(2-propyl)oxybenzene (13.2 g) as a mobile, slightly brown oil which was used without further purification.

Aufarbeitung

  1. temperatureat reflux
  2. temperatureThe solution was heated
  3. temperatureat reflux for 4 days
  4. temperatureAfter cooling
  5. customthe solvent was evaporated
  6. dissolutionthe residue was dissolved in ether
  7. customThe ether phase was separated

Quellen und Nachweise

ORD-Eintrag
ord-c383f4cca4a8441ba22214930705beff
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352988B2

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