benzyl N-[1-(hydroxymethyl)cyclohexyl]carbamate → (1-Aminocyclohexyl)methanol

HRID 276251

Reaktionsgleichung

Reaktionsgleichung von HRID 276251
C(OC([NH:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][C:12]1([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Komponenten

4

Edukt 1

HCID 18316421benzyl N-[1-(hydroxymethyl)cyclohexyl]carbamate

Produkt 1

HCID 409153(1-Aminocyclohexyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A slurry of 1-(benzyloxycarbonylamino)-1-(hydroxymethyl)cyclohexane (4.0 g, 15 mmol) and 10% Pd/C (0.40 g) in MeOH (75 ml) was stirred under H2 (1 atm.) for 1 h, then treated with Celite®. The resulting mixture was filtered and concentrated under reduced pressure to give 1-amino-1-(hydroxymethyl)cyclohexane.

Aufarbeitung

  1. additiontreated with Celite®
  2. filtrationThe resulting mixture was filtered
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-b96e79cfef164e66b54433207daa4f14
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

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