Cyclohexanecarboxylic acid → N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide

HRID 27666

Reaktionsgleichung

Reaktionsgleichung von HRID 27666
C([C:4]1[C:8](C)=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[S:6][C:5]=1[NH:16][C:17]([CH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[O:18])(O)=O.[Li]I.O.O.C1(C(O)=O)CCCCC1>N1C(C)=CC(C)=CC=1C>[C:10]1([C:7]2[S:6][C:5]([NH:16][C:17]([CH:19]3[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]3)=[O:18])=[CH:4][CH:8]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 7413Cyclohexanecarboxylic acidHCID 70592634N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamideHCID 178526965HCID 178526965, Verbindung

Produkt 1

HCID 23341601N-(5-Phenylthiophen-2-yl)cyclohexanecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 79532,4,6-TrimethylpyridineLösungsmittel

Versuchsvorschrift

This compound (m.p. 174° C.) was prepared from N-(3-carboxy-methyl-5-phenyl-2-thienyl)-cyclohexane carboxamide (31.1 g, 0.1 mole) and LiI.2H2O (48.1 g, 0.32 mole) by refluxing in collidine (125 ml.) according to the procedure of Example 53 (a). This compound was also prepared according to the procedure of Example 53(b), using cyclohexane carboxylic acid as the acylating agent. The products of the two processes were spectrally identical and had a melting point of 175° C.

Aufarbeitung

  1. customThis compound was also prepared

Quellen und Nachweise

ORD-Eintrag
ord-fa69975da3e14d579e8308f5c3d04eb7
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04222946

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