Hydrochloric Acid → Ethyl 3-(methylamino)propanoate hydrochloride

HRID 276928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 276928
C(O[C:9]([N:11]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])C)=O)C1C=CC=CC=1.[ClH:20]>[Pd].CO>[ClH:20].[CH3:9][NH:11][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 22629164ethyl 3-(N-benzyloxycarbonyl-N-methylamino)propionate

Produkt 1

HCID 22629233Ethyl 3-(methylamino)propanoate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 3-(N-benzyloxycarbonyl-N-methylamino)propionate (8 g), 10% palladium on carbon (1.6 g, 50% wet), conc.-hydrochloric acid (5.1 ml) in methanol (160 ml) was stirred for 5 hours at room+temperature under hydrogen atmosphere. Catalyst was removed by filtration and mother liquor was concentrated in reduced pressure to give ethyl 3-(methylamino)propionate hydrochloride (4.31 g).

Aufarbeitung

  1. customCatalyst was removed by filtration and mother liquor
  2. concentrationwas concentrated in reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ea7c440a1d1f4f47a3e2e68b04467b2e
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06355640B1

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