Methanesulfonate → alpha-Cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate

HRID 27926

Reaktionsgleichung

Reaktionsgleichung von HRID 27926
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([OH:13])=[O:12].S([O-])(=O)(=O)C.[C:22]([CH:24](O)[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:26]=1)#[N:23].C(OCC)(=O)C.CCCCCC>C1COCC1.CN(C=O)C.C1COCC1.CCOCC>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([O:13][CH:24]([C:22]#[N:23])[C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:26]=1)=[O:12]

Komponenten

8

Edukt 4

HCID 85257MethanesulfonateHCID 93218Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)-HCID 21226206Ethyl acetate hexaneHCID 233403922-(1-Benzothiophen-2-yl)-3-methylbutanoic acid

Produkt 1

HCID 23340427alpha-Cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 3283Diethyl EtherLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 21974620tetrahydrofuran N,N-dimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2-(2-benzothienyl)-3-methylbutanoic acid (0.5 g, 21.4 mmol) and KHCO3 (21.4 mmol) in 10 ml THF/DMF (1:1) is stirred for 10 minutes. Then the mesylate of α-cyano-3-phenoxybenzyl alcohol (0.65 g, 21.4 mmol) in 3 ml THF is added followed by stirring overnight. The mixture is diluted with 100 ml ether, washed with water and saturated NaCl, dried and solvent stripped to yield crude product. The product is isolated using thin layer chromatography developing with 15% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(2-benzothienyl)-3-methyl-butanoate, viscous liquid.

Aufarbeitung

  1. stirringby stirring overnight
  2. washwashed with water and saturated NaCl
  3. customdried
  4. customto yield crude product
  5. customThe product is isolated

Quellen und Nachweise

ORD-Eintrag
ord-3e7d6f062fd54e5f8e5ba42178928462
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04224330

Verknüpfte Notizen

Wird geladen…