Propionic Acid → 1-(2-Ethyl-4-methyloxazol-5-yl)ethanone

HRID 2796

Reaktionsgleichung

Reaktionsgleichung von HRID 2796
Cl[CH:2]([C:6](=[O:8])[CH3:7])[C:3](=O)[CH3:4].[C:9]([NH2:13])(=[O:12])[CH2:10][CH3:11].C(O)(=O)CC.[OH-].[Na+]>>[C:6]([C:2]1[O:12][C:9]([CH2:10][CH3:11])=[N:13][C:3]=1[CH3:4])(=[O:8])[CH3:7]

Komponenten

5

Edukt 4

HCID 1032Propionic AcidHCID 6578PropionamideHCID 14798Sodium HydroxideHCID 743283-Chloro-2,4-pentanedione

Produkt 1

HCID 189363281-(2-Ethyl-4-methyloxazol-5-yl)ethanone

Versuchsvorschrift

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

Aufarbeitung

  1. extractionextracted with dichloromethane
  2. washThe combined extracts were washed with brine
  3. customdried
  4. customthe solvent removed
  5. customto leave a brown oil which
  6. distillationwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

Quellen und Nachweise

ORD-Eintrag
ord-eb5bfefcbfd94ea0be77c604cb53b9bd
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731335

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