2-Chloroethanol → 2-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-ol

HRID 279614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 279614
Cl[CH2:2][CH2:3][OH:4].[SH:5][C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1>[OH-].[Na+]>[OH:4][CH2:3][CH2:2][S:5][C:6]1[N:7]([CH3:11])[CH:8]=[CH:9][N:10]=1

Komponenten

4

Edukt 2

HCID 342-ChloroethanolHCID 178480602HCID 178480602, Verbindung

Produkt 1

HCID 27748452-[(1-methyl-1H-imidazol-2-yl)thio]ethan-1-olAusbeute 82,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

2-Chloroethanol (3 g, 37 mmol) was added to a solution of 2-mercapto-1-methylimidazole (3.45 g, 30 mmol) in 2M aqueous sodium hydroxide solution (30 ml) and the mixture heated at 100° C. for 2 hours. The mixture was allowed to cool and extracted with ethyl acetate. The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give 2-(2-hydroxyethylthio)-1-methylimidazole (3.9 g, 82%).

Aufarbeitung

  1. temperatureto cool
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined extracts were dried (MgSO4)
  4. customthe solvent removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-b6a95ba821bb46a792c2e62c3b437173
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06362336B1

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