Dimethylformamide → HCID 14456868, Verbindung

HRID 279782Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 279782
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH3:19][N:20](C)C=O.[C-]#N.[Na+]>O>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:20]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867, Verbindung

Produkt 1

HCID 14456868HCID 14456868, VerbindungAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 1.2 g (3.3 millimoles) of 1-(2,4-dimethoxy-benzyl)-4-iodomethyl-2-azetidinone and 5 ml of dimethyl formamide is stirred with 0.35 g (7 millimoles) of sodium cyanide at room temperature for 48 hours. The solution is poured onto 30 ml of water and extracted five times with 20 ml of ether each. The etheral solution is dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated in vacuo. Thus 0.6 g of 4-cyanomethyl-1-(2,4-dimethoxy-benzyl)-2-azetidinone are obtained. Yield: 70%.

Aufarbeitung

  1. extractionextracted five times with 20 ml of ether each
  2. dry with materialThe etheral solution is dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe filtrate is evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7f060409e59a45c5ae2a43fc44b3b30b
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04587049

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