1H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester → 1H-Imidazole-4,5-dimethanol

HRID 279846

Reaktionsgleichung

Reaktionsgleichung von HRID 279846
[NH:1]1[C:5]([C:6](OC)=[O:7])=[C:4]([C:10](OC)=[O:11])[N:3]=[CH:2]1>O1CCCC1>[OH:7][CH2:6][C:5]1[N:1]=[CH:2][NH:3][C:4]=1[CH2:10][OH:11]

Komponenten

3

Edukt 1

HCID 768101H-Imidazole-4,5-dicarboxylic acid, 4,5-dimethyl ester

Produkt 1

HCID 5736291H-Imidazole-4,5-dimethanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Reflux dimethyl 4,5 imidazole dicarboxylate (1.8 g) in THF (tetrahydrofuran) with 2.5 equivalents of LAH lithium aluminum hydride). Neutralize with NH4Cl solution and filter. Concentrate the filtrate under vacumm and extract the product with ethanol. Remove the solvent, filtrate through alumina using a THF solvent to give the title compound.

Aufarbeitung

  1. filtrationNeutralize with NH4Cl solution and filter
  2. concentrationConcentrate the filtrate under vacumm
  3. extractionextract the product with ethanol
  4. customRemove the solvent, filtrate through alumina using a THF solvent

Quellen und Nachweise

ORD-Eintrag
ord-12483586f11b49f08bb683b241c74f50
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04587241

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