3-(Trifluoromethyl)phenylglyoxal → N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine

HRID 280310

Reaktionsgleichung

Reaktionsgleichung von HRID 280310
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9]([CH:11]=O)=[O:10])[CH:6]=[CH:7][CH:8]=1.[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][NH2:25])=[CH:18][CH:17]=1>>[CH3:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][NH:25][CH2:11][CH:9]([OH:10])[C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:14])([F:13])[F:1])[CH:4]=2)=[CH:18][CH:17]=1

Komponenten

3

Edukt 2

HCID 27832843-(Trifluoromethyl)phenylglyoxalHCID 125642703-(4-Methylphenyl)propan-1-amine

Produkt 1

HCID 23322159N-(3-(4-Methylphenyl)propyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine

Versuchsvorschrift

The title compound was prepared in the manner described in Example 9 using 3-trifluoromethylphenylglyoxal and 3-(4-methylphenyl)propanamine. Recrystallization of the chromatographed material from hexane gave the title compound m.p. 96-98. τ(CDCl3) 8.0-8.5 (2H, m), 7.7 (3H, s), 7.0-7.5 (6H, m+2H, disappears with D2O), 5.3 (1H, dd), 2.9 (4H, s), 2.3-2.7 (4H, m).

Aufarbeitung

  1. customThe title compound was prepared in the manner
  2. customRecrystallization of the chromatographed material from hexane

Quellen und Nachweise

ORD-Eintrag
ord-a43d5886af2b4183ae5193bb0f0e2f07
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04588749

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