Formaldehyde → 7-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

HRID 280627Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 280627
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][NH:15][CH3:16].[CH2:17]=O>Cl.C(O)C>[ClH:13].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([CH2:14][N:15]([CH3:17])[CH3:16])[C:9]2=[O:12])=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 2527317-Bromo-1,2,3,4-tetrahydronaphthalen-1-one

Produkt 1

HCID 233209337-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 7-bromo-1-tetralone (4.50 g), dimethylamine hydrochloride (2.50 g), paraformaldehyde (1.0 g), ethanol (6 ml) and concentrated hydrochloric acid (4 drops) was heated under reflux for two hours and cooled. The mixture was diluted with a few ml. of acetone and the solid was filtered off, washed with a little acetone and dried to give 7-bromo-2-dimethylaminomethyl-1-tetralone hydrochloride, m.p. 169°-171°, pure enough for further reaction.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for two hours
  3. temperaturecooled
  4. additionThe mixture was diluted with a few ml
  5. filtrationof acetone and the solid was filtered off
  6. washwashed with a little acetone
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d3d0fbaff7b24b45bce90989ea617b9a
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04590200

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