Ammonia → 6-Chloro-N~2~-cyclopropyl-1,3,5-triazine-2,4-diamine

HRID 28110Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 28110
[CH:1]1([NH:4][C:5]2[N:10]=[C:9](Cl)[N:8]=[C:7]([Cl:12])[N:6]=2)[CH2:3][CH2:2]1.O1CCOCC1.[NH3:19]>CCOCC>[CH:1]1([NH:4][C:5]2[N:6]=[C:7]([Cl:12])[N:8]=[C:9]([NH2:19])[N:10]=2)[CH2:2][CH2:3]1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 222540664,6-Dichloro-N-cyclopropyl-1,3,5-triazin-2-amine

Produkt 1

HCID 233389806-Chloro-N~2~-cyclopropyl-1,3,5-triazine-2,4-diamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

138 g of 2-cyclopropylamino-4,6-dichloro-s-triazine are added at a slightly elevated tmeperature and with vigorous stirring to a mixture of 675 ml of dioxane and 135 ml of ether. After cooling to room temperature, 101 ml of 25%, aqueous ammonia are added dropwise over a period of 20 minutes. The reaction mixture is heated to 50° C., stirred for 16 hours and then concentrated by evaporation under water jet vaccum. The dry riesidue is diluted with 500 ml. of water and after stirring for 1 hour at room temperature, the tiny white crystals formed are separated by filtering under suction and dried under water jet vacuum at 80° C. 217 g. of 2-cyclopropylamino-4-chloro-6-amino-s-triazine are obtained.

Aufarbeitung

  1. temperatureThe reaction mixture is heated to 50° C.
  2. concentrationconcentrated by evaporation under water jet vaccum
  3. additionThe dry riesidue is diluted with 500 ml
  4. stirringof water and after stirring for 1 hour at room temperature
  5. customthe tiny white crystals formed
  6. customare separated
  7. filtrationby filtering under suction
  8. customdried under water jet vacuum at 80° C

Quellen und Nachweise

ORD-Eintrag
ord-bc7eb56cbb4e48e69d5c8706d0e6837f
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04225598

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