Hydrochloric Acid → 1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

HRID 2820

Reaktionsgleichung

Reaktionsgleichung von HRID 2820
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])(O)[CH3:7])=[CH:2]1.Cl.C(OCC)C.C(=O)([O-])O.[Na+]>C(Cl)(Cl)Cl>[O:1]1[CH:5]=[CH:4][C:3]([C:6]([C:9]2[O:13][CH:12]=[N:11][C:10]=2[CH3:14])=[CH2:7])=[CH:2]1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 516892Sodium BicarbonateHCID 97941531-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

Produkt 1

HCID 189362911-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

1-(3-Furyl)-1-(4-methyl-5-oxazolyl)ethanol (900 mg) in dry chloroform was treated with 1M anhydrous hydrogen chloride in diethylether (1.1 equivalents). After 10 minutes at room temperature, aqueous sodium hydrogen carbonate was added and the mixture was extracted with dichloromethane. The material thus obtained was purified by flash chromatography to give the title compound as an almost colourless liquid.

Aufarbeitung

  1. extractionthe mixture was extracted with dichloromethane
  2. customThe material thus obtained
  3. customwas purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-f8ae87d4cdb04743b3be2fcbfdc05511
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731335

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