Furfurylamine → 2-Amino-3-cyano-4-furfurylaminoquinoline

HRID 28384

Reaktionsgleichung

Reaktionsgleichung von HRID 28384
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:15]([NH2:21])[C:16]1[O:20][CH:19]=[CH:18][CH:17]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:21][CH2:15][C:16]2[O:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 3438FurfurylamineHCID 114811212-Amino-3-cyano4-chloroquinoline

Produkt 1

HCID 222737212-Amino-3-cyano-4-furfurylaminoquinolineAusbeute 44,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

10 g of 2-amino-3-cyano-4-chloroquinoline is heated with 19 g of furfurylamine at 120° C. for 3 hours. The reaction mixture is cooled to 25  C. and mixed 6 times with 50 ml of water. The crystals are filtered off and dried. The resulting product is recrystallized from 60 ml of N,N-dimethylformamide, to obtain 5.8 g of the title compound, m.p.: 206° C.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled to 25  C
  2. filtrationThe crystals are filtered off
  3. customdried
  4. customThe resulting product is recrystallized from 60 ml of N,N-dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-5bda3d78ea3743e7a3af617fb0032deb
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419977B2

Verknüpfte Notizen

Wird geladen…