(2-Thienylmethyl)amine → 2-Amino-3-cyano-4-thenylaminoquinoline

HRID 28385

Reaktionsgleichung

Reaktionsgleichung von HRID 28385
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[CH2:20][NH2:21]>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:21][CH2:20][C:16]2[S:15][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Komponenten

4

Edukt 2

HCID 34005(2-Thienylmethyl)amineHCID 114811212-Amino-3-cyano4-chloroquinoline

Produkt 1

HCID 222737202-Amino-3-cyano-4-thenylaminoquinolineAusbeute 49,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

10 g of 2-amino-3-cyano-4-chloroquinoline is heated with 19 g of thienylmethylamine at 115° C. for 4 hours. The reaction mixture is cooled to 25° C. and mixed 6 times with 50 ml of water. The crystals are filtered off, washed 2 times with 50 ml of water and dried. The resulting product is recrystallized from 60 ml of N,N-dimethylformamide, to obtain 6.8 g pale yellow title compound, m.p.: 208-209° C.

Aufarbeitung

  1. filtrationThe crystals are filtered off
  2. washwashed 2 times with 50 ml of water
  3. customdried
  4. customThe resulting product is recrystallized from 60 ml of N,N-dimethylformamide

Quellen und Nachweise

ORD-Eintrag
ord-5776aca0e38b491ba070be5d1aece8fa
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419977B2

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