Hydrochloric Acid → 5-Acetyl-1,3-benzoxazol-2(3H)-one

HRID 28392

Reaktionsgleichung

Reaktionsgleichung von HRID 28392
C(N(CC)CC)C.ClC(Cl)(O[C:12](=[O:18])[O:13][C:14](Cl)(Cl)Cl)Cl.[NH2:20][C:21]1[CH:26]=[C:25]([C:27]([CH3:29])=[O:28])[CH:24]=[CH:23]C=1O.Cl>C1COCC1>[CH3:29][C:27]([C:25]1[CH:24]=[CH:23][C:14]2[O:13][C:12](=[O:18])[NH:20][C:21]=2[CH:26]=1)=[O:28]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 94429TriphosgeneHCID 137241423'-Amino-4'-hydroxyacetophenone

Produkt 1

HCID 151135715-Acetyl-1,3-benzoxazol-2(3H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

7.8 ml of triethylamine and 2.75 g (0.0093 mol) of triphosgene are added to a mixture of 4.2 g (0.0277 mol) of 2-amino-4-methylcarbonylphenol in 100 ml of THF, at 0° C. The mixture is stirred at room temperature for 1 hour, poured into 100 ml of a 0.5N HCl solution and extracted with ethyl acetate, the organic phase is dried and the solvent is evaporated off. The compound of the title is obtained.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customthe organic phase is dried
  3. customthe solvent is evaporated off
  4. customThe compound of the title is obtained

Quellen und Nachweise

ORD-Eintrag
ord-24754a8a8d0d46a5b2104443d26209ef
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419974B2

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