Sodium Hydroxide → HCID 178418387, Verbindung

HRID 2852

Reaktionsgleichung

Reaktionsgleichung von HRID 2852
[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[CH2:4][C:5](=[O:7])[CH3:6].[OH-].[Na+].[Cl-].[C:13]1([N+:19]#[N:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>O>[CH3:1][N:2]([CH3:9])[C:3](=[O:8])[C:4](=[N:20][NH:19][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:5](=[O:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 16278DimethylacetoacetamideHCID 60992Benzenediazonium chloride

Produkt 1

HCID 178418387HCID 178418387, VerbindungAusbeute 42,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

4.5 g (0.035 mol) of N,N-dimethyl-3-oxobutyramide, a solution of 4.9 g (0.122 mol) of NaOH in 45 ml of water and 0.037 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 0%→100%) obtaining 3.5 g of the title compound which was used as such in the subsequent step. M.p.=131°-133° C.

Aufarbeitung

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 0%→100%)

Quellen und Nachweise

ORD-Eintrag
ord-b070703fd73b4d8680fe6f71c91c67d7
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731322

Verknüpfte Notizen

Wird geladen…