Sodium Hydroxide → HCID 178418482, Verbindung

HRID 2853

Reaktionsgleichung

Reaktionsgleichung von HRID 2853
[O:1]=[C:2]([CH3:7])[CH2:3][C:4]([NH2:6])=[O:5].[OH-].[Na+].[Cl-].[C:11]1([N+:17]#[N:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[C:11]1([NH:17][N:18]=[C:3]([C:2](=[O:1])[CH3:7])[C:4]([NH2:6])=[O:5])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 80077Acetoacetamide

Produkt 1

HCID 178418482HCID 178418482, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

5.0 g (0.049 mol) of 3-oxobutyramide, a solution of 6.9 g (0.171 mol) of NaOH in 75 ml of water and 0.051 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which was used as such in the subsequent step. M.p.=146°-147° C.

Aufarbeitung

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel(EtOAc) obtaining 3 g of the title compound which

Quellen und Nachweise

ORD-Eintrag
ord-fa496a7ce126439c8a04c703ffcedc08
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731322

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