Sodium Hydroxide → HCID 178418269, Verbindung

HRID 2854

Reaktionsgleichung

Reaktionsgleichung von HRID 2854
[CH:1]([N:4]([CH:11]([CH3:13])[CH3:12])[C:5](=[O:10])[CH2:6][C:7](=[O:9])[CH3:8])([CH3:3])[CH3:2].[OH-].[Na+].[Cl-].[C:17]1([N+:23]#[N:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O>[CH:11]([N:4]([CH:1]([CH3:2])[CH3:3])[C:5](=[O:10])[C:6](=[N:24][NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:7](=[O:9])[CH3:8])([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 123185413-Oxo-N,N-di(propan-2-yl)butanamide

Produkt 1

HCID 178418269HCID 178418269, VerbindungAusbeute 68,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

Aufarbeitung

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 95:5)

Quellen und Nachweise

ORD-Eintrag
ord-ee71b009ed3f4c28bab5abd1c42abd9d
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731322

Verknüpfte Notizen

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