Sodium Azide → 2-Azido-1-(4-nitrophenyl)ethanone

To a mixture of 2-bromo-1-(4-nitro-phenyl)-ethanone (2.0 g, 8.2 mmol) in tetrahydrofuran (15 ml) and ethanol (15 ml) was added a solution of sodium azide (586 mg, 9.8 mmol) in water (1.5 ml). After stirring for 20 minutes, the mixture was concentrated under reduced pressure. The residue was treated with saturated aqueous sodium chloride solution (200 ml) and extracted with ethyl acetate (200 ml). The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to give crude 2-azido-1-(4-nitrophenyl)-ethanone.

1. concentrationthe mixture was concentrated under reduced pressure
2. additionThe residue was treated with saturated aqueous sodium chloride solution (200 ml)
3. extractionextracted with ethyl acetate (200 ml)
4. dry with materialThe organic layer was dried over magnesium sulfate
5. concentrationconcentrated under reduced pressure

ORD-Eintrag

ord-5782194270b84c77a8c805d693f2ce3c

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07419984B2