Propane-2-sulfonamide → 3-Methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester

HRID 29305

Reaktionsgleichung

Reaktionsgleichung von HRID 29305
[CH:1]([S:4]([NH2:7])(=[O:6])=[O:5])([CH3:3])[CH3:2].[CH2:8]([O:10][C:11]([C:13]1[O:14][C:15]2[CH:22]=[CH:21][CH:20]=[C:19](OS(C(F)(F)F)(=O)=O)[C:16]=2[C:17]=1[CH3:18])=[O:12])[CH3:9]>>[CH2:8]([O:10][C:11]([C:13]1[O:14][C:15]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:7][S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])[C:16]=2[C:17]=1[CH3:18])=[O:12])[CH3:9]

Komponenten

3

Edukt 2

HCID 3549191Propane-2-sulfonamideHCID 865990263-Methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester

Produkt 1

HCID 687134743-Methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl esterAusbeute 23 %

Versuchsvorschrift

Coupling of isopropylsulfonamide with 3-methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester was carried out according to Example 36, Step 1 to give 3-methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester in 23% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.4 (t, J=6.4 Hz, 9 H) 2.9 (t, 3 H) 3.5 (m, 1 H) 4.5 (q, J=7.1 Hz, 2 H) 6.6 (s, 1 H) 7.4 (m, 3 H).

Quellen und Nachweise

ORD-Eintrag
ord-b95a7ebe74064e24a5a8ee037cf564da
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07420001B2

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