Water → 2-(1,1-Dimethylethyl)phenoxypropene

HRID 2953

Reaktionsgleichung

Reaktionsgleichung von HRID 2953
[CH2:1](Br)[CH:2]=[CH2:3].[C:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])([CH3:8])([CH3:7])[CH3:6].C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O>[CH3:7][C:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH:1]=[CH:2][CH3:3])([CH3:8])[CH3:6]

Komponenten

6

Edukt 4

HCID 962WaterHCID 69232-Tert-ButylphenolHCID 7841Allyl bromideHCID 11430Potassium Carbonate

Produkt 1

HCID 676312242-(1,1-Dimethylethyl)phenoxypropene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

Aufarbeitung

  1. temperatureat reflux temperature for 50 hours
  2. customthe resulting layers were separated
  3. extractionThe aqueous layer was extracted with 600 ml of diethyl ether
  4. extractionextract
  5. dry with materialthe resulting solution was dried over sodium sulfate overnight
  6. customAfter sodium sulfate removal
  7. customthe solvent was evaporated
  8. customto provide

Quellen und Nachweise

ORD-Eintrag
ord-f43f465340624f4daaa306b11664c6ec
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731336

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