4-Toluenesulfonyl chloride → 3-iodo-N,4-dimethylbenzamide

HRID 2967

Reaktionsgleichung

Reaktionsgleichung von HRID 2967
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5](O)=[O:6].S(Cl)(C1C=CC(C)=CC=1)(=O)=O.Cl.[CH3:24][NH2:25]>>[CH3:24][NH:25][C:5]([C:4]1[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([I:1])[CH:3]=1)=[O:6]

Komponenten

4

Edukt 3

HCID 73974-Toluenesulfonyl chlorideHCID 6216403-Iodo-4-methylbenzoic acidHCID 6364545Methylamine hydrochloride

Produkt 1

HCID 196884403-iodo-N,4-dimethylbenzamide

Versuchsvorschrift

A solution of 1.0 mmol of 3-iodo-4-methylbenzoic acid, 1.2 mmol of TsCl, and 25 mmol of Py was stirred for 3 h and then 5 mmol of methylamine hydrochloride was added and stirring continued for 5 h. Chromatography provided N-methyl-(3-iodo-4-methylphenyl)carboxamide.

Quellen und Nachweise

ORD-Eintrag
ord-d5a686fbf7b9481c9a917b96b78bc8ab
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731432

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