4-Toluenesulfonyl chloride → 3-iodo-N,4-dimethylbenzamide
Reaktionsgleichung
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5](O)=[O:6].S(Cl)(C1C=CC(C)=CC=1)(=O)=O.Cl.[CH3:24][NH2:25]>>[CH3:24][NH:25][C:5]([C:4]1[CH:8]=[CH:9][C:10]([CH3:11])=[C:2]([I:1])[CH:3]=1)=[O:6]Komponenten
4
Versuchsvorschrift
A solution of 1.0 mmol of 3-iodo-4-methylbenzoic acid, 1.2 mmol of TsCl, and 25 mmol of Py was stirred for 3 h and then 5 mmol of methylamine hydrochloride was added and stirring continued for 5 h. Chromatography provided N-methyl-(3-iodo-4-methylphenyl)carboxamide.
Quellen und Nachweise
- ORD-Eintrag
- ord-d5a686fbf7b9481c9a917b96b78bc8ab
- Quelldatensatz
- uspto-grants-1998_03
- Patentnummer
- US05731432
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