Water → HCID 69200296, Verbindung

HRID 29771Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 29771
B(Br)(Br)Br.C[O:6][C:7]1[CH:21]=[CH:20][C:10]2[N:11]3[CH2:19][CH2:18][CH2:17][C:12]3=[N:13][S:14](=[O:16])(=[O:15])[C:9]=2[CH:8]=1.O>C(Cl)Cl>[CH2:19]1[N:11]2[C:12](=[N:13][S:14](=[O:15])(=[O:16])[C:9]3[CH:8]=[C:7]([OH:6])[CH:21]=[CH:20][C:10]=32)[CH2:17][CH2:18]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 25134Boron tribromideHCID 11253769HCID 11253769, Verbindung

Produkt 1

HCID 69200296HCID 69200296, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

A solution of BBr3 (68.75 mmol) in 25 ml of methylene chloride is added dropwise to a solution, cooled to 0° C., of 27.5 mmol of 7-methoxy-2,3-dihydro-1H-pyrrolo[2,1-c]-[1,2,4]benzothiadiazine 5,5-dioxide in 350 ml of methylene chloride. Stirring is carried out at ambient temperature for 24 hours. The reaction mixture is poured into a mixture of ice and water, and the suspension is stirred for 30 minutes. The precipitate is filtered off, rinsed several times with water, filtered under suction and dried in vacuo to yield the expected product.

Aufarbeitung

  1. stirringthe suspension is stirred for 30 minutes
  2. filtrationThe precipitate is filtered off
  3. washrinsed several times with water
  4. filtrationfiltered under suction
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ea1e4a520a4b42bba5b2093fa403e469
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423034B2

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