Hydrazine hydrate (1:1) → 7-Methoxy-4-phenylphthalazin-1(2H)-one

HRID 29919

Reaktionsgleichung

Reaktionsgleichung von HRID 29919
O.[NH2:2][NH2:3].[C:4]([C:12]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][C:13]=1[C:14](O)=[O:15])(=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C>[CH3:22][O:21][C:18]1[CH:17]=[C:13]2[C:12]([C:4]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)=[N:2][NH:3][C:14]2=[O:15])=[CH:20][CH:19]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 3340802-Benzoyl-5-methoxybenzoic acid

Produkt 1

HCID 692140027-Methoxy-4-phenylphthalazin-1(2H)-oneAusbeute 13,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

10.55 g (210 mmol) of hydrazine hydrate are added to a solution of 5.4 g of 2-benzoyl-5-methoxy-benzoic acid in 50 mL of ethanol, and the mixture is refluxed for 2 hours 30 minutes. The reaction medium is cooled and then filtered. The precipitate obtained is washed with ethanol and then dried under reduced pressure at 40° C. 740 mg of product are obtained in the form of a white solid.

Aufarbeitung

  1. temperaturethe mixture is refluxed for 2 hours 30 minutes
  2. temperatureThe reaction medium is cooled
  3. filtrationfiltered
  4. customThe precipitate obtained
  5. washis washed with ethanol
  6. customdried under reduced pressure at 40° C

Quellen und Nachweise

ORD-Eintrag
ord-e8f6f113ac9d4958b23dbe1a795271f7
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423030B2

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