2-Bromo-5-methoxybenzoic acid → 2-Acetyl-5-methoxybenzoic acid

Reaktionsgleichung

Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.CON(C)[C:21](=[O:23])[CH3:22]>>[C:21]([C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])(=[O:23])[CH3:22]

Komponenten

Edukt 3

HCID 899062-Bromo-5-methoxybenzoic acid

HCID 537505N-Methoxy-N-methylacetamide

HCID 178418339Butyllithium

Produkt 1

HCID 201632832-Acetyl-5-methoxybenzoic acid

Versuchsvorschrift

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methylacetamide. It is used in crude form in the following reaction.