Sodium Hydroxide → 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

HRID 30044

Reaktionsgleichung

Reaktionsgleichung von HRID 30044
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:16][CH2:15]2)=[CH:5][CH:4]=1.Cl.[NH+]1C=CC=CC=1.[OH-].[Na+]>>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:15][CH2:16][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:18][CH2:19]2)=[CH:5][CH:4]=1

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 115546837-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine2×HCID 21584435Pyridinium hydrochloride

Produkt 1

HCID 1363949037-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amineAusbeute 86,8 %

Reaktionsbedingungen

Temperatur
210 °C

Versuchsvorschrift

A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.

Aufarbeitung

  1. temperatureThe reaction medium is cooled
  2. washA precipitate forms, which is washed with water and with dichloromethane
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e9b7e2235a7a47bfab84ebdfc02c564b
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423030B2

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