Propionyl chloride → 1-{4-[6-Amino-5-(2-fluoro-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-propan-1-one
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[O:9])=[CH:6][CH:5]=[C:4]([NH:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:3]=1.[C:24](Cl)(=[O:27])[CH2:25][CH3:26]>>[NH2:1][C:2]1[N:3]=[C:4]([NH:17][CH:18]2[CH2:19][CH2:20][N:21]([C:24](=[O:27])[CH2:25][CH3:26])[CH2:22][CH2:23]2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16]Komponenten
3
Versuchsvorschrift
The title compound was prepared from [2-Amino-6-(piperidin-4-ylamino)-pyridin-3-yl]-(2-fluoro-phenyl)-methanone (Example 9) and propionyl chloride (Aldrich 98%) using the procedure described in Example 12. HRMS, observed: 370.1807, Calcd for M+: 370.1805.
Quellen und Nachweise
- ORD-Eintrag
- ord-15409d617f494192978b52004eeb6668
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07423051B2
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