Propionyl chloride → 1-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-propan-1-one

HRID 30128

Reaktionsgleichung

Reaktionsgleichung von HRID 30128
F[C:2](F)(F)C(O)=O.[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13]N=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:10]=1.[C:33](Cl)(=[O:36])[CH2:34][CH3:35]>>[NH2:8][C:9]1[N:10]=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][N:30]([C:33](=[O:36])[CH2:34][CH3:35])[CH2:29][CH2:28]2)[CH:2]=[CH:13][C:14]=1[C:15](=[O:16])[C:17]1[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=1[O:24][CH3:25]

Komponenten

3

Edukt 2

HCID 62324Propionyl chlorideHCID 21070627[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt

Produkt 1

HCID 115964671-{4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidin-1-yl}-propan-1-one

Versuchsvorschrift

The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and propionyl chloride (Aldrich 98%) using the procedure described in Example 24. HRMS, observed: 401.1988, Calcd for (M+H)+: 401.1984.

Quellen und Nachweise

ORD-Eintrag
ord-51a8141126be4a24955fdb8816211cb2
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423051B2

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