Methanol → 5-[1-(4-Amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

HRID 30235

Reaktionsgleichung

Reaktionsgleichung von HRID 30235
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:10](=[O:23])[NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH3:13])=[CH:8][CH:9]=1)=[O:4].CO>[Pd].C1COCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([C:10](=[O:23])[NH:11][CH:12]([C:14]2[CH:15]=[CH:16][C:17]([NH2:20])=[CH:18][CH:19]=2)[CH3:13])=[CH:8][CH:9]=1)=[O:4]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 691350675-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

Produkt 1

HCID 691350895-[1-(4-Amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 500 mg (1.497 mmol) 5-[1-(4-Nitro-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester, 200 mg palladium on charcoal (10%), 10 ml methanol and 5 ml THF was hydrogenated at 30 mbar for 3 h. The catalyst was filtered off, the solvent was evaporated to give 5-[1-(4-amino-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f10a87577de4744a4a01bec0963bec2
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423060B2

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