Potassium Carbonate → 4,5,6,7,7a,8-Hexahydro-3bH-3-thia-6-aza-cyclopenta[alpha]indene

Temperatur

22 °C

The product of step f) (1.16 g, 4.3 mmol) in dichloroethane (21 ml) was treated with K2CO3 (2.38 g, 17.2 mmol) and Ace-Cl (1.86 ml, 17.2 mmol) at 800C for 16 hours. Next, the reaction mixture was filtered, concentrated and the residue was dissolved in anhydrous MeOH (25 ml) and stirred for 1 hour at 22° C. The MeOH was concentrated and triturated with ether to give 874 mg (94%) of the subtitle compound. MS calculated for C10H13NS+H 180, observed 180.

1. filtrationNext, the reaction mixture was filtered
2. concentrationconcentrated
3. dissolutionthe residue was dissolved in anhydrous MeOH (25 ml)
4. concentrationThe MeOH was concentrated
5. customtriturated with ether

ORD-Eintrag

ord-2996ca1e74824e76982146f3153ba8e9

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07423056B2