Diethyl Malonate → HCID 178418389, Verbindung

Reaktionsgleichung

[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[NH:5][C:4]([CH3:10])(N)[N:3]=1.[O-]CC.[Na+].[Na].Cl.C(N)(=N)C.C(OCC)(=O)CC(OCC)=O>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:10])[N:3]=1

Komponenten

Edukt 5

HCID 7761Diethyl Malonate

HCID 67170Acetamidine monohydrochloride

HCID 2723922Sodium ethoxide

HCID 5360545Sodium

HCID 1784183454,6-Dihydroxy-2-methylpyrimidinamine

Produkt 1

HCID 178418389HCID 178418389, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

Versuchsvorschrift

The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.