4-tert-Butyl-1-fluoro-2-nitrobenzene → 5-Tert-butyl-2-fluoroaniline
Reaktionsgleichung
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([N+:12]([O-])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]([NH2:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To 4-tert-butyl-1-fluoro-2-nitrobenzene in methanol was added a catalytic amount of palladium on carbon (10%). The mixture was allowed to stir for 1 h at room temperature under an atmosphere of hydrogen. Mixture was filtered though celite and concentrated to afford 5-tert-butyl-2-fluorobenzenamine.
Aufarbeitung
- filtrationMixture was filtered though celite and
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-dd1a10403b924b2e82b2b82757e54840
- Quelldatensatz
- uspto-grants-2008_09
- Patentnummer
- US07423150B2
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