Morpholine → 4-(3-Nitrophenyl)morpholine

HRID 31400

Reaktionsgleichung

Reaktionsgleichung von HRID 31400
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CS(C)=O>[N+:8]([C:4]1[CH:3]=[C:2]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 98231-Fluoro-3-nitrobenzene

Produkt 1

HCID 12532734-(3-Nitrophenyl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

3-Fluoronitrobenzene (10 g, 71 mmol) was added to a solution of morpholine (34 ml, 390 mmol) in dimethylsulfoxide (120 ml) and heated at 110° C. for 60 hours. The reaction was cooled and poured onto water (800 ml). The desired product precipitated and was collected by filtration. The orange solid was dried in vacuo and used in subsequent reactions without further purification (13.7 g, 66 mmol).

Aufarbeitung

  1. temperatureThe reaction was cooled
  2. additionpoured onto water (800 ml)
  3. customThe desired product precipitated
  4. filtrationwas collected by filtration
  5. customThe orange solid was dried in vacuo
  6. customused in subsequent reactions without further purification (13.7 g, 66 mmol)

Quellen und Nachweise

ORD-Eintrag
ord-37b9b77e1244444086434082d264cf48
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425555B2

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