Cyclobutanone → 2-(((4-(5,9-Dioxaspiro[3.5]non-7-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Reaktionsgleichung
[Na:1].[CH2:2]1[C:6]2([O:11][CH2:10][CH:9]([CH2:12][O:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([CH2:20][S:21]([C:23]4[NH:27][C:26]5[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=5[N:24]=4)=[O:22])[C:15]=3[CH3:32])[CH2:8][O:7]2)[CH2:5][CH2:4]C1.OCC(CO)CO.C1(=O)CCC1>>[Na:1].[CH2:2]1[C:6]2([O:11][CH2:10][CH:9]([CH2:12][O:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([CH2:20][S:21]([C:23]4[NH:27][C:26]5[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=5[N:24]=4)=[O:22])[C:15]=3[CH3:32])[CH2:8][O:7]2)[CH2:5][CH2:4]1Komponenten
4
Edukt 3
Produkt 1
Versuchsvorschrift
The same procedure as in the steps (21a) and (21b) of Example 21 was repeated using 2-(hydroxymethyl)-1,3-propanediol and cyclobutanone to obtain the title compound (265 mg, total yield: 6.2%) as a light yellow solid.