2-Imidazoline → 1-(4-Ethylphenyl)-2-imidazolylethan-1-one

HRID 31779

Reaktionsgleichung

Reaktionsgleichung von HRID 31779
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[CH:7][CH:6]=1)=[O:4].[NH:13]1[CH2:17][CH2:16][N:15]=[CH:14]1>C(#N)C>[CH2:11]([C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][C:14]2[NH:13][CH:17]=[CH:16][N:15]=2)=[CH:6][CH:7]=1)[CH3:12]

Komponenten

4

Edukt 2

HCID 681562-ImidazolineHCID 124019512-Bromo-1-(4-ethylphenyl)ethan-1-one

Produkt 1

HCID 221425781-(4-Ethylphenyl)-2-imidazolylethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel2×

Versuchsvorschrift

1 mmol of 2-bromo-1-(4-ethylphenyl)ethan-1-one in acetonitrile was added drop wise to 5.5 mmol imidazoline in acetonitrile at room temperature for fourteen hours. The reaction mixture was concentrated in vacuo and diluted with water and ethyl acetate. The solution was extracted three times with ethyl acetate and dried over sodium sulfate to obtain 1-(4-ethylphenyl)-2-imidazolylethan-1-one.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water and ethyl acetate
  3. extractionThe solution was extracted three times with ethyl acetate
  4. dry with materialdried over sodium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-24ee89c2f0684d92a2fe9090065cfceb
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425557B2

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